This session at the Public Health and Midwifery World Conference (PHMWC) 2025 will address the complex challenges posed by substance abuse during pregnancy and its impact on maternal and fetal health. The session will focus on screening methods, early interventions, and evidence-based treatment approaches, including harm-reduction strategies and counseling programs. Discussions will also emphasize overcoming stigma, improving access to care, and integrating mental health and addiction services into prenatal care systems. This session will equip healthcare providers with tools to support pregnant women struggling with substance abuse and improve health outcomes for both mothers and babies by sharing successful models and policy frameworks.